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About 45 million Indians are at a risk of chronic heart failure, according to a new research that has identified a genetic mutation in the people of South Asian ancestry. An international team of researchers, led by the Centre for Cellular and Molecular Biology (CCMB) at Hyderabad, reports in Monday’s issue of Nature Genetics, a monthly journal, that the gene that encodes for a certain cardiac protein has a deletion that increases the risk of cradiomyopathy sevenfold. Cardiomyopathy is characterized by weakening of heart muscles and people carrying this mutation have a lifelong predisposition to heart failure. Analysing the DNA of 800 cardiac patients undergoing treatment at nine hospitals across India, researchers found that a 25 base pair deletion in the gene making the heart protein, called myosin binding protein-C (MYBPC3), makes people susceptible to this disorder.  Read more at http://www.livemint.com/2009/01/18235922/Genetic-mutation-behind-heart.html